Where Can I Buy Glucosamine
Glucosamine and chondroitin are popular supplements used to treat osteoarthritis (OA). According to one estimate from the National Institutes of Health, 6.5 million adults, or 2.6% of the population, has used one or both of these products. Although studies on glucosamine and chondroitin have been mixed, some evidence suggests they may help relieve OA joint pain and stiffness.
where can i buy glucosamine
In many European countries, these supplements are a prescribed treatment for OA. In the U.S., the recommendations on glucosamine and chondroitin are more moderate, due to the mixed results of studies.
The ideal form of glucosamine has also caused dissent in the research community. Some studies show an advantage to glucosamine sulfate; others to glucosamine hydrochloride. One study that compared the two glucosamine forms head to head found no real difference between them.
Gluco Blu is N-Butyryl Glucosamine (GlcNBu), a breakthrough analog of glucosamine developed as an improved form to provide clinical benefits. Rejensa is the only joint care chew on the market today that contains this revolutionary, clinically proven form of glucosamine.
My vet gave me a Rejensa sample, which you must have made available to her. This was very helpful to me because all other glucosamine products Festus simply did not like. He would spit them all out! Either he really likes Rejensa, or he is eating them quickly out of competition with the other two dogs in the house who are taking it at the same time.
You should also be cautious about taking glucosamine if you have diabetes. Glucosamine might increase your blood sugar level and it may mean that you need to adjust your treatment to make sure it carried on working. There are several reports of interaction between glucosamine and anti-diabetic treatments. There are also some reports of possible interaction with chemotherapy drugs and drugs that lower blood cholesterol.
A review article of 18 trials investigating the effectiveness of glucosamine sulphate in treating osteoarthritis was published in 2005. A further four trials published since 2007 evaluated the effect of glucosamine sulphate in the treatment of hip and knee osteoarthritis. A second review article compared the clinical effectiveness and safety of glucosamine sulphate with those of non-steroidal anti-inflammatory drugs (NSAIDs).
The 64 participants with osteoarthritis of the knee in this study received either 500 mg glucosamine sulphate three times a day or 400 mg vitamin E made from palm oil once a day for six months. Both groups improved in pain and function, but there was no difference between them.
60 participants with primary osteoarthritis in either one or both knees were randomised to receive a 1500 mg sachet of glucosamine sulphate or a placebo. After 12 weeks, there were no improvements in the placebo group but those who received glucosamine reported significant improvements in resting and moving pain, overall pain, stiffness and function. The improvements in these final three measures lasted for 20 weeks. In the treatment group, reported side-effects were heartburn and an all-over itch.
If you're looking for a supplement that may ease your joint pain, glucosamine might be worth a try. Some studies show it gives relief for mild to moderate knee osteoarthritis, and it may work for other joints, too.
The glucosamine in your body helps keep up the health of your cartilage -- the rubbery tissue that cushions bones at your joints. But as you get older, your levels of this compound begin to drop, which leads to the gradual breakdown of the joint.
Some people have also used glucosamine to try to treat rheumatoid arthritis and other conditions, such as inflammatory bowel disease, asthma, allergies, chronic venous insufficiency, sports injuries, temporomandibular joint problems (TMJ), and long-term low back pain. So far, though, there's not much scientific evidence that it works for those problems.
In most studies on treating osteoarthritis, the typical dose was 500 milligrams of glucosamine sulfate, three times a day. Ask your doctor what they recommend for you. Some experts suggest you take it with meals to prevent an upset stomach.
Risks. If you have a shellfish allergy, be cautious about using glucosamine because you could have a reaction. Also, check with your doctor before taking supplements if you have diabetes, kidney disease, heart disease, bleeding disorders, or high blood pressure.
Interactions. Check with your doctor before you use glucosamine if you take other medicines, including heart drugs, blood thinners, and diabetes drugs. Also, glucosamine isn't recommended for children or women who are pregnant or breastfeeding, because there isn't enough evidence yet about whether it's safe for those groups.
Glucosamine can be found naturally in the body and is used by the body as one of the building blocks of cartilage. Glucosamine can also be taken as a pill as a supplement to the diet, or sometimes as an injection. It can come in combination with other supplements (such as chondroitin), or by itself in the form of glucosamine hydrochloride or sulphate. The usual dose recommended on packages is 1500 mg per day or 500 mg three times a day.
In Europe, glucosamine is prescribed by health care providers. But in North America, people can buy glucosamine supplements without a prescription. This means that, in North America, glucosamine is not regulated and the pills may or may not truly contain the amount described on the label.
Pain: The high quality studies showed that pain improved about the same whether people took glucosamine or fake pills. If all of the studies are examined (including low quality and old studies), then glucosamine improved pain more than fake pills.
Studies testing only the Rotta brand of glucosamine (including low quality and older studies) showed that glucosamine improved pain more than fake pills. People who took fake pills had a pain score of 6 points on a 0 to 20 scale. People who took the Rotta brand of glucosamine rated their pain 3 points lower than people who did not take glucosamine.
Function: The high quality studies show that glucosamine improved function more than fake pills when measured by one type of scale, but improved the same amount as fake pills when measured by another scale.
Studies testing only the Rotta brand of glucosamine (including low quality and older studies) showed that glucosamine improved function more than fake pills. People who took fake pills had a function score of 22 points on a 0 to 68 scale. People who took the Rotta brand of glucosamine had their ability to function improve by 2 points compared to people who did not take glucosamine.
Pooled results from studies using a non-Rotta preparation or adequate allocation concealment failed to show benefit in pain and WOMAC function while those studies evaluating the Rotta preparation showed that glucosamine was superior to placebo in the treatment of pain and functional impairment resulting from symptomatic OA.
This update includes 25 studies with 4963 patients. Analysis restricted to studies with adequate allocation concealment failed to show any benefit of glucosamine for pain (based on a pooled measure of different pain scales) and WOMAC pain, function and stiffness subscales; however, it was found to be better than placebo using the Lequesne index (standardized mean difference (SMD) -0.54; 95% confidence interval (CI) -0.96 to -0.12). Collectively, the 25 RCTs favoured glucosamine with a 22% (change from baseline) improvement in pain (SMD -0.47; 95% CI -0.72 to -0.23) and a 11% (change from baseline) improvement in function using the Lequesne index (SMD -0.47; 95% CI -0.82 to -0.12). However, the results were not uniformly positive and the reasons for this remain unexplained. WOMAC pain, function and stiffness outcomes did not reach statistical significance.
RCTs in which the Rotta preparation of glucosamine was compared to placebo found glucosamine superior for pain (SMD -1.11; 95% CI -1.66 to -0.57) and function (Lequesne index SMD -0.47; 95% CI -0.82 to -0.12). Pooled results for pain (SMD -0.05; 95% CI -0.15 to 0.05) and function using the WOMAC index (SMD -0.01; 95% CI -0.13 to 0.10) in those RCTs using a non-Rotta preparation of glucosamine did not reach statistical significance. Two RCTs using the Rotta preparation showed that glucosamine was able to slow radiological progression of OA of the knee over a three-year period (mean difference (MD) 0.32; 95% CI 0.05 to 0.58).
Glucosamine sulfate has a long history and an extensive body of research highlighting its role in protecting cartilage, the shock-absorbing, gel-like material located between the joints. As the key precursor to cartilage formation, glucosamine sulfate supports connective tissue health to provide full support for joint comfort, as well as integrity and movement, while maintaining normal inflammatory balance. Glucosamine sulfate is also a precursor to chondroitin sulfate and hyaluronic acid, both of which are natural compounds found in the synovial fluid of cartilage. The Glucosamine Sulfate formula provides maximum support for healthy joint function.
Although exact mechanisms of action are yet to be established, research suggests that glucosamine supplementation helps modulate cytokine production in addition to directly stimulating chondrocytes (cartilage cells that help produce and maintain a healthy cartilage matrix), while aiding in the incorporation of sulfur into cartilage. Glucosamine has been found to maintain normal inflammatory balance and alleviate oxidative stress.
There is some evidence that glucosamine can affect liver function, though it's not clear if that's the case in healthy people or people who already have liver damage. In one study, just two of 23 people with a liver disease who took the supplements showed changes that suggested liver damage.Talk to your healthcare provider before taking any supplement.
Glucosamine is one of the four most common supplements taken by older people; the others include multivitamins and vitamin D. They also take them with prescription drugs. Researchers have found possible interactions with the drug Glucophage (metformin), and with diuretics like Lasix (furosemide), that reduce glucosamine effects. There were no such findings with vitamins. 041b061a72